No efficacy use now reaches an A grade. The best-supported signals are testosterone or male-hormone, libido, and exercise-performance claims, while blood-glucose, cholesterol, and several hormone-related claims look mixed rather than firmly established. It still appears generally well-tolerated, but it can amplify diabetes medications.
Each row is a different health effect. A means the support looks strongest, B likely helpful, C mixed or modest, and — not enough human evidence yet.
Papers are individual studies. Research reviews summarize evidence from multiple studies, such as systematic reviews and meta-analyses.
Safety is graded separately from benefits. A favorable safety label is not the same as a benefit claim or a green light for every situation.
Dose, form, and the proprietary-extract picture.
Products that pass third-party quality testing.
Grades come from 30 unique research papers indexed from PubMed — including 6 meta-analyses, 5 systematic reviews, and 19 randomized trials. Several positive testosterone trials are funded by extract manufacturers. Independently-funded replications are sparser. Results from proprietary extracts (Testofen, Furosap, Libifem, Fenfuro) may not generalize to generic fenugreek. Each supplement is graded by health effect using a certainty × effect matrix applied across PubMed evidence per health effect. Cochrane reviews and high-quality systematic reviews carry the most weight. From abstract-only data, "high certainty" is rare — most A grades come from moderate certainty plus consistent meaningful-positive evidence. See Methodology for full detail.
Read the full methodology → · Download all 30 citations (PDF)