Check supplement effects.Backed by real research.

Sleep quality is now the clearest supported use on the page. Stress, anxiety, cortisol, cognition, exercise, testosterone, and metabolic claims all look more mixed under the current grading system than the old headline suggested.

43 papers reviewed · 12 health effects reviewed

Research reviewed, but no outcome currently meets the evidence threshold.

10 papers reviewed · 5 health effects reviewed

The clearest signal on this page is around blood pressure, vascular function, and exercise endurance, but the evidence for other effects on this page is still mixed.

28 papers reviewed · 4 health effects reviewed

The clearest current evidence is for metabolic syndrome and type 2 diabetes or glucose control.

57 papers reviewed · 6 health effects reviewed

Heavily marketed for hair, skin, and nails — but those claims still sit below the grading threshold.

29 papers reviewed · 5 health effects reviewed

The strongest current support is for cholesterol & blood fats. Other uses on this page have narrower, weaker, or not-yet-clear evidence.

27 papers reviewed · 5 health effects reviewed

The strongest current support is for blood pressure in non-pregnant adults.

26 papers reviewed · 2 health effects reviewed

The cleanest current human evidence is in pregnancy-related brain-development research, where choline may support some early memory and attention measures in children, but results are not uniform and many studies come from special settings.

46 papers reviewed · 4 health effects reviewed

The strongest current support is for blood pressure. Other uses on this page have narrower, weaker, or not-yet-clear evidence.

22 papers reviewed · 4 health effects reviewed

The strongest current support is for joint Pain Osteoarthritis and skin Elasticity Wrinkles Skin Hydration.

69 papers reviewed · 8 health effects reviewed

Evidence is modest and scattered rather than anchored by one standout cardiovascular area.

125 papers reviewed · 8 health effects reviewed

The clearest current evidence remains mixed or uncertain, with the more defensible questions focused on Recurrent UTI Prevention Recurrent Urinary Tract Infection.

8 papers reviewed · 1 health effect reviewed

The most-studied performance supplement. The strongest current evidence is for power or sprint performance and added benefit when paired with resistance training, with probably-helpful evidence for broader exercise performance, strength, cognition, and fatigue.

169 papers reviewed · 17 health effects reviewed

The clearest current evidence is for osteoarthritis and joint pain. Curcumin also looks probably helpful for metabolic markers, lipid effects, fatty liver (NAFLD) or liver health, and chemotherapy-side-effect support, but the broad anti-inflammatory and mood-marketing picture is more mixed under the current grading system than the old A-heavy page implied.

199 papers reviewed · 8 health effects reviewed

No efficacy use now reaches an A grade. The best-supported signals are testosterone or male-hormone, libido, and exercise-performance claims, while blood-glucose, cholesterol, and several hormone-related claims look mixed rather than firmly established.

29 papers reviewed · 9 health effects reviewed

The clearest supported uses here are correcting low folate status and targeted use around conception or early pregnancy.

50 papers reviewed · 3 health effects reviewed

The strongest current support is for blood pressure, vascular function & arterial stiffness, and blood sugar & insulin markers.

21 papers reviewed · 6 health effects reviewed

The strongest current support is for pregnancy-related nausea, nausea after surgery, and chemotherapy-related nausea.

40 papers reviewed · 7 health effects reviewed

The clearest signal on this page is around dementia symptom support (clinical context) and walking distance in intermittent claudication, but the evidence for other effects on this page is still mixed.

27 papers reviewed · 7 health effects reviewed

The clearest current human evidence is still in knee osteoarthritis, where glucosamine has mixed signals for pain and stiffness and a separate, cautious signal for slower worsening on X-rays in some long-term studies.

50 papers reviewed · 3 health effects reviewed

Human evidence for concentrated green tea extract and EGCG is still mixed.

17 papers reviewed · 4 health effects reviewed

The clearest current evidence remains mixed or uncertain, with the more defensible questions focused on Skin hydration / dry skin support, Skin elasticity / firmness, and Wrinkle depth / photoaging appearance.

8 papers reviewed · 3 health effects reviewed

The strongest current evidence is in PCOS, where inositol looks probably helpful for cycle regularity, insulin-related markers, and testosterone-related hormone markers.

32 papers reviewed · 3 health effects reviewed

The clearest current human evidence suggests a likely benefit for Anxiety Symptoms Generalized Anxiety Disorder.

19 papers reviewed · 1 health effect reviewed

Research reviewed, but no outcome currently meets the evidence threshold.

0 papers reviewed · 0 health effects reviewed

Moderate evidence supports anxiety or acute stress response, sleep quality, and pediatric attention effects.

32 papers reviewed · 7 health effects reviewed

Research reviewed, but no outcome currently meets the evidence threshold.

4 papers reviewed · 1 health effect reviewed

The strongest current support is for anxiety symptoms / generalized anxiety disorder.

12 papers reviewed · 2 health effects reviewed

Research reviewed, but no outcome currently meets the evidence threshold.

7 papers reviewed · 4 health effects reviewed

Research reviewed, but no outcome currently meets the evidence threshold.

4 papers reviewed · 5 health effects reviewed

Research reviewed, but no outcome currently meets the evidence threshold.

5 papers reviewed · 2 health effects reviewed

Probably helpful for glucose control, constipation, and some broader metabolic health effects.

70 papers reviewed · 18 health effects reviewed

The clearest current human evidence suggests a likely benefit for Appetite Satiety Energy Intake.

5 papers reviewed · 1 health effect reviewed

The best-supported use is delayed sleep phase syndrome. Probably helpful for general adult sleep onset or quality, sleep in children with neurodevelopmental conditions, shift-work sleep issues, and some secondary effects, but blood pressure, metabolic, and older-adult sleep findings look more mixed under the current grading system.

226 papers reviewed · 11 health effects reviewed

Research reviewed, but no outcome currently meets the evidence threshold.

0 papers reviewed · 0 health effects reviewed

The clearest current human evidence is for male fertility and sperm-parameter outcomes, with a smaller and less certain signal for ovulation-related outcomes in polycystic ovary syndrome (PCOS).

10 papers reviewed · 2 health effects reviewed

Reliably raises NAD+ blood levels in the trials available. A small signal also exists for muscle-function signals, but the marketed longevity, biological-age, and cognitive benefits remain unproven in humans.

18 papers reviewed · 8 health effects reviewed

The evidence picture is much less top-heavy under the current grading system.

323 papers reviewed · 10 health effects reviewed

The clearest signal on this page is around IBS abdominal pain, but the evidence for other effects on this page is still mixed.

6 papers reviewed · 4 health effects reviewed

The strongest current support is for kidney stone recurrence. Other uses on this page have narrower, weaker, or not-yet-clear evidence.

38 papers reviewed · 3 health effects reviewed

The strongest current support is for LDL Total Cholesterol HDL Triglycerides Lipid Profile.

55 papers reviewed · 6 health effects reviewed

Research reviewed, but no outcome currently meets the evidence threshold.

3 papers reviewed · 1 health effect reviewed

The strongest current support is for LDL cholesterol, total cholesterol, and cholesterol and blood fats.

8 papers reviewed · 4 health effects reviewed

The strongest current support is for fertility Reproductive Hormones and metabolic Health Insulin Resistance Type 2 Diabetes Glucose.

155 papers reviewed · 11 health effects reviewed

The clearest signal on this page is around exercise Performance Endurance Physical Performance, but the evidence for other effects on this page is still mixed.

18 papers reviewed · 7 health effects reviewed

The clearest public signal is still in depressive symptoms and broader anxiety or stress contexts, but the evidence for other effects on this page remains mixed rather than strongly established.

28 papers reviewed · 7 health effects reviewed

The clearest signal on this page is around osteoarthritis pain and function, but the evidence for other effects on this page is still mixed.

13 papers reviewed · 3 health effects reviewed

The strongest current support is for active Comparator Tamsulosin Finasteride Alpha Blockers 5ARI.

52 papers reviewed · 6 health effects reviewed

The clearest signal on this page is around thyroid Function Autoimmune Thyroiditis Hashimotos Thyroid Antibodies and type 2 Diabetes Glucose Insulin Resistance Metabolic Syndrome, but the evidence for other effects on this page is still mixed.

25 papers reviewed · 4 health effects reviewed

Research reviewed, but no outcome currently meets the evidence threshold.

1 paper reviewed · 1 health effect reviewed

The strongest current support is for lipids Total Cholesterol LDL HDL Triglycerides Dyslipidemia.

14 papers reviewed · 2 health effects reviewed

The strongest current support is for depression symptoms (mild to moderate).

24 papers reviewed · 4 health effects reviewed

The clearest current evidence remains mixed or uncertain, with the more defensible questions focused on Lipids Total Cholesterol LDL HDL Triglycerides Dyslipidemia.

7 papers reviewed · 1 health effect reviewed

The strongest current support is for testosterone Free Testosterone Male Hormones.

6 papers reviewed · 3 health effects reviewed

No health effect currently reaches grade A or B under the new rubric. Sexual-function, testosterone, exercise, and metabolic claims are either mixed or too thin to grade, rather than clearly supported.

10 papers reviewed · 7 health effects reviewed

The strongest current support is for anemia Megaloblastic Anemia Pernicious Anemia.

21 papers reviewed · 3 health effects reviewed

No efficacy use now reaches grade A under the current grading system. The strongest supported signals are gout or serum uric acid reduction and symptom-management during cancer treatment, while common-cold, cardiovascular, cognition, iron, and wound-healing claims are more mixed, and eye-health prevention looks unsupported.

179 papers reviewed · 8 health effects reviewed

Effects depend strongly on whether the person is deficient. Probably helpful for muscle strength in older adults, immune-related effects, asthma or COPD, skin conditions, and blood sugar control, but many headline claims still land in mixed territory.

727 papers reviewed · 19 health effects reviewed

The clearest current human evidence suggests a likely benefit for Bone density / bone health support.

27 papers reviewed · 1 health effect reviewed

The evidence picture is weaker under the current grading system than the old percentage-based grades implied.

175 papers reviewed · 7 health effects reviewed