The evidence picture is much less top-heavy under the current grading system. Blood pressure is the strongest supported health effect, while triglycerides, cardiovascular events, pregnancy-related uses, depression, and cognition mostly land in mixed territory, and dry eye now looks negative rather than clearly helpful. Form and dose still matter, but the broad "works for everything" reputation overstates what the current grading supports.
Each row is a different health effect. A means the support looks strongest, B likely helpful, C mixed or modest, and — not enough human evidence yet.
Papers are individual studies. Research reviews summarize evidence from multiple studies, such as systematic reviews and meta-analyses.
Dose, form and timing based on trials in the database.
Products that pass third-party quality testing.
Product quality data coming soon
Product recommendations are being built from USP Verified, NSF Certified, and Labdoor test data. Products will only appear here after the supplement itself clears the evidence bar above — and only if the product passes third-party purity testing.
Grades come from 323 unique research papers indexed from PubMed — including 130 meta-analyses, 48 systematic reviews, 18 Cochrane reviews, and 101 randomized trials. Omega-3's literature has unusual structural complexity: trials use different forms (EPA-dominant, DHA-dominant, balanced fish oil, ALA flaxseed, algae oil, krill oil) at different doses, and most reviews legitimately pool these forms together. The grading rubric treats those pooled-form reviews as usable evidence — they're a property of the literature, not a quality flaw — and applies a subgroup-A rule that lets health effects grade A when reviews consistently report positive findings within a defined subgroup, even if the pooled effect looks modest. Depression graded A under this rule because reviews consistently report positive effects in moderate-to-severe depression and EPA-major formulations. Each supplement is graded by health effect using a certainty × effect matrix applied across PubMed evidence per health effect. Cochrane reviews and high-quality systematic reviews carry the most weight. From abstract-only data, "high certainty" is rare — most A grades come from moderate certainty plus consistent meaningful-positive evidence. See Methodology for full detail.
Read the full methodology → · Download all 323 citations (PDF)